A NEW EXPERIMENTAL PLATFORM FACILITATES ASSESSMENT OF THE TRANSCRIPTIONAL AND CHROMATIN LANDSCAPES OF AGING YEAST

A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

Replicative aging of Saccharomyces cerevisiae is an established model system for eukaryotic cellular aging.A limitation in yeast lifespan studies has been the difficulty of separating old cells from young cells in large quantities.We engineered a new platform, the Miniature-chemostat Aging Device (MAD), that enables purification of aged cells at su

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Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response.

Advancements in molecular biology have unveiled multiple breast cancer promoting pathways and potential therapeutic targets.Large randomized clinical trials remain DIARICHESSE the ultimate means of validating therapeutic efficacy, but they require large cohorts of patients and are lengthy and costly.A useful approach is to conduct a window of oppor

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Analysis of the impact of the introduced restrictions caused by the new COVID-19 infection in the field of education on the results of the unified state exam in various constituent entities of the Russian Federation

Since the end of 2019, all countries of the world have faced a rapidly increasing level of disease caused by the new coronavirus infection COVID-19, which in turn has led to the introduction of a number of restrictions in various areas of life.Educational institutions in many countries were forced to transfer students to a remote mode of work, for

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First Expert Elicitation of Knowledge on Possible Drivers of Observed Increasing Human Cases of Tick-Borne Encephalitis in Europe

Tick-borne encephalitis (TBE) is a viral disease endemic in Eurasia.The virus is mainly transmitted to humans via ticks and occasionally via the consumption of unpasteurized milk products.The European Centre for Disease Prevention and Control reported an increase in TBE incidence over the past years in Europe as well as the emergence of the disease

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